1LEH

LEUCINE DEHYDROGENASE FROM BACILLUS SPHAERICUS

1LEH の概要

• エントリーDOI: 10.2210/pdb1leh/pdb
• 分子名称: LEUCINE DEHYDROGENASE (2 entities in total)
• 機能のキーワード: oxidoreductase
• 由来する生物種: Lysinibacillus sphaericus
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 78172.45

構造登録者

Baker, P.J.,Turnbull, A.P.,Sedelnikova, S.E.,Stillman, T.J.,Rice, D.W. (登録日: 1995-06-09, 公開日: 1996-12-23, 最終更新日: 2024-02-14)

主引用文献

Baker, P.J.,Turnbull, A.P.,Sedelnikova, S.E.,Stillman, T.J.,Rice, D.W.
A role for quaternary structure in the substrate specificity of leucine dehydrogenase.
Structure, 3:693-705, 1995

PubMed Abstract: Glutamate, phenylalanine and leucine dehydrogenases catalyze the NAD(P)(+)-linked oxidative deamination of L-amino acids to the corresponding 2-oxoacids, and sequence homology between these enzymes clearly indicates the existence of an enzyme superfamily related by divergent evolution. We have undertaken structural studies on a number of members of this family in order to investigate the molecular basis of their differential amino acid specificity.

PubMed: 8591046
DOI: 10.1016/S0969-2126(01)00204-0

実験手法

X-RAY DIFFRACTION (2.2 Å)