1LDT

COMPLEX OF LEECH-DERIVED TRYPTASE INHIBITOR WITH PORCINE TRYPSIN

Summary for 1LDT

• Entry DOI: 10.2210/pdb1ldt/pdb
• Descriptor: TRYPSIN, TRYPTASE INHIBITOR, CALCIUM ION, ... (4 entities in total)
• Functional Keywords: complex (hydrolase-inhibitor), hydrolase, inhibitor, inflammation, tryptase, complex (hydrolase-inhibitor) complex, complex (hydrolase/inhibitor)
• Biological source: Hirudo medicinalis (medicinal leech); More
• Cellular location: Secreted, extracellular space: P00761
• Total number of polymer chains: 2
• Total formula weight: 28284.19

Authors

Stubbs, M.T. (deposition date: 1997-05-15, release date: 1998-05-20, Last modification date: 2024-04-03)

• Primary citation: Stubbs, M.T.,Morenweiser, R.,Sturzebecher, J.,Bauer, M.,Bode, W.,Huber, R.,Piechottka, G.P.,Matschiner, G.,Sommerhoff, C.P.,Fritz, H.,Auerswald, E.A.; The three-dimensional structure of recombinant leech-derived tryptase inhibitor in complex with trypsin. Implications for the structure of human mast cell tryptase and its inhibition.; J.Biol.Chem., 272:19931-19937, 1997; PubMed: 9242660; DOI: 10.1074/jbc.272.32.19931

Experimental method

X-RAY DIFFRACTION (1.9 Å)