1LBE

APLYSIA ADP RIBOSYL CYCLASE

1LBE の概要

• エントリーDOI: 10.2210/pdb1lbe/pdb
• 分子名称: ADP RIBOSYL CYCLASE (2 entities in total)
• 機能のキーワード: hydrolase, nad(+) nucleosidase, nadase
• 由来する生物種: Aplysia californica (California sea hare)
• 細胞内の位置: Cytoplasmic vesicle: P29241
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 59159.89

構造登録者

Prasad, G.S.,Mcree, D.E.,Stura, E.A.,Levitt, D.G.,Lee, H.C.,Stout, C.D. (登録日: 1996-09-18, 公開日: 1997-09-17, 最終更新日: 2024-11-06)

主引用文献

Prasad, G.S.,McRee, D.E.,Stura, E.A.,Levitt, D.G.,Lee, H.C.,Stout, C.D.
Crystal structure of Aplysia ADP ribosyl cyclase, a homologue of the bifunctional ectozyme CD38.
Nat.Struct.Biol., 3:957-964, 1996

PubMed Abstract: ADP ribosyl cyclase synthesizes the novel secondary messenger cyclic ADP ribose (cADPR) utilizing NAD as a substrate. The enzyme shares extensive sequence similarity with two lymphocyte antigens, CD38 and BST-1, which hydrolyse as well as synthesize cADPR. The crystal structure provides a model for these cell surface enzymes. Cyclase contains two spatially separated pockets composed of sequence conserved residues, suggesting that the cyclization reaction may entail use of distinct sites. The enzyme dimer encloses a cavity which may entrap the intermediate, ADP ribose.

PubMed: 8901875
DOI: 10.1038/nsb1196-957

実験手法

X-RAY DIFFRACTION (2.4 Å)