1LB8

Crystal structure of the Non-desensitizing GluR2 ligand binding core mutant (S1S2J-L483Y) in complex with AMPA at 2.3 resolution

1LB8 の概要

• エントリーDOI: 10.2210/pdb1lb8/pdb
• 分子名称: Glutamate receptor 2, (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID (3 entities in total)
• 機能のキーワード: ampa receptor, glur2, s1s2, ligand-binding core, non-desensitizing, point mutation, l483y, agonist, membrane protein
• 由来する生物種: Rattus norvegicus (Norway rat); 詳細
• 細胞内の位置: Cell membrane; Multi-pass membrane protein: P19491
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 58915.73

構造登録者

Sun, Y.,Olson, R.,Horning, M.,Armstrong, N.,Mayer, M.,Gouaux, E. (登録日: 2002-04-02, 公開日: 2002-06-05, 最終更新日: 2023-08-16)

• 主引用文献: Sun, Y.,Olson, R.,Horning, M.,Armstrong, N.,Mayer, M.,Gouaux, E.; Mechanism of glutamate receptor desensitization.; Nature, 417:245-253, 2002; PubMed: 12015593; DOI: 10.1038/417245a

実験手法

X-RAY DIFFRACTION (2.3 Å)