1L9K

dengue methyltransferase

Summary for 1L9K

DescriptorRNA-DIRECTED RNA POLYMERASE, SULFATE ION, S-ADENOSYL-L-HOMOCYSTEINE, ... (4 entities in total)
Functional Keywordsmethyltransferase fold, complex with s-adenosyl-l-homocysteine, transferase
Biological sourceDengue virus
Cellular locationCapsid protein C: Virion (Potential). Peptide pr: Secreted (By similarity). Small envelope protein M: Virion membrane; Multi-pass membrane protein (By similarity). Envelope protein E: Virion membrane; Multi- pass membrane protein (By similarity). Non-structural protein 1: Secreted. Non-structural protein 2A-alpha: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Non-structural protein 2A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease subunit NS2B: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). RNA-directed RNA polymerase NS5: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity) P12823
Total number of polymer chains1
Total molecular weight35261.75
Authors
Egloff, M.P.,Benarroch, D.,Selisko, B.,Romette, J.L.,Canard, B. (deposition date: 2002-03-25, release date: 2003-03-25, Last modification date: 2011-07-13)
Primary citation
Egloff, M.P.,Benarroch, D.,Selisko, B.,Romette, J.L.,Canard, B.
An RNA cap (nucleoside-2'-O-) methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization
Embo J., 21:2757-2768, 2002
PubMed: 12032088 (PDB entries with the same primary citation)
DOI: 10.1093/emboj/21.11.2757
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.4 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.257191.9%6.2%6.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution