1L8R

Structure of the Retinal Determination Protein Dachshund Reveals a DNA-Binding Motif

1L8R の概要

• エントリーDOI: 10.2210/pdb1l8r/pdb
• 分子名称: Dachshund (2 entities in total)
• 機能のキーワード: winged-helix, transcription
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: Q9UI36
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22570.08

構造登録者

Kim, S.S.,Zhang, R.,Braunstein, S.E.,Joachimiak, A.,Cvekl, A.,Hegde, R.S. (登録日: 2002-03-21, 公開日: 2002-06-26, 最終更新日: 2024-10-30)

主引用文献

Kim, S.S.,Zhang, R.G.,Braunstein, S.E.,Joachimiak, A.,Cvekl, A.,Hegde, R.S.
Structure of the retinal determination protein Dachshund reveals a DNA binding motif.
Structure, 10:787-795, 2002

PubMed Abstract: The Dachshund proteins are essential components of a regulatory network controlling cell fate determination. They have been implicated in eye, limb, brain, and muscle development. These proteins cannot be assigned to any recognizable structural or functional class based on amino acid sequence analysis. The 1.65 A crystal structure of the most conserved domain of human DACHSHUND is reported here. The protein forms an alpha/beta structure containing a DNA binding motif similar to that found in the winged helix/forkhead subgroup of the helix-turn-helix family. This unexpected finding alters the previously proposed molecular models for the role of Dachshund in the eye determination pathway. Furthermore, it provides a rational framework for future mechanistic analyses of the Dachshund proteins in several developmental contexts.

PubMed: 12057194
DOI: 10.1016/S0969-2126(02)00769-4

実験手法

X-RAY DIFFRACTION (1.65 Å)