1L7H
Crystal structure of R292K mutant influenza virus neuraminidase in complex with BCX-1812
Summary for 1L7H
Entry DOI | 10.2210/pdb1l7h/pdb |
Related | 1L7F 1L7G 2QWE 2QWH |
Descriptor | neuraminidase, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total) |
Functional Keywords | n9 neuraminidase, hydrolase, influenza, glycosylated protein, bcx-1812, r292k mutant |
Biological source | Influenza A virus |
Cellular location | Virion membrane (By similarity): P03472 |
Total number of polymer chains | 1 |
Total formula weight | 46301.39 |
Authors | Smith, B.J.,McKimm-Breshkin, J.L.,McDonald, M.,Fernley, R.T.,Varghese, J.N.,Colman, P.M. (deposition date: 2002-03-15, release date: 2002-05-29, Last modification date: 2021-10-27) |
Primary citation | Smith, B.J.,McKimm-Breshkin, J.L.,McDonald, M.,Fernley, R.T.,Varghese, J.N.,Colman, P.M. Structural studies of the resistance of influenza virus neuramindase to inhibitors. J.Med.Chem., 45:2207-2212, 2002 Cited by PubMed: 12014958DOI: 10.1021/jm010528u PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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