1L6Z

CRYSTAL STRUCTURE OF MURINE CEACAM1A[1,4]: A CORONAVIRUS RECEPTOR AND CELL ADHESION MOLECULE IN THE CEA FAMILY

1L6Z の概要

• エントリーDOI: 10.2210/pdb1l6z/pdb
• 関連するPDBエントリー: 1E4J 1HNF
• 分子名称: biliary glycoprotein C, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: ig-like domain, cea family, coronavirus receptor, cell adhesion
• 由来する生物種: Mus musculus (house mouse)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25783.86

構造登録者

Tan, K.,Zelus, B.D.,Meijers, R.,Liu, J.-H.,Bergelson, J.M.,Duke, N.,Zhang, R.,Joachimiak, A.,Holmes, K.V.,Wang, J.-H. (登録日: 2002-03-14, 公開日: 2002-09-14, 最終更新日: 2024-10-16)

主引用文献

Tan, K.,Zelus, B.D.,Meijers, R.,Liu, J.-H.,Bergelson, J.M.,Duke, N.,Zhang, R.,Joachimiak, A.,Holmes, K.V.,Wang, J.-H.
CRYSTAL STRUCTURE OF MURINE sCEACAM1a[1,4]: A CORONAVIRUS RECEPTOR IN THE CEA FAMILY
Embo J., 21:2076-2086, 2002

PubMed Abstract: CEACAM1 is a member of the carcinoembryonic antigen (CEA) family. Isoforms of murine CEACAM1 serve as receptors for mouse hepatitis virus (MHV), a murine coronavirus. Here we report the crystal structure of soluble murine sCEACAM1a[1,4], which is composed of two Ig-like domains and has MHV neutralizing activity. Its N-terminal domain has a uniquely folded CC' loop that encompasses key virus-binding residues. This is the first atomic structure of any member of the CEA family, and provides a prototypic architecture for functional exploration of CEA family members. We discuss the structural basis of virus receptor activities of murine CEACAM1 proteins, binding of Neisseria to human CEACAM1, and other homophilic and heterophilic interactions of CEA family members.

PubMed: 11980704
DOI: 10.1093/emboj/21.9.2076

実験手法

X-RAY DIFFRACTION (3.32 Å)