1L0Q

Tandem YVTN beta-propeller and PKD domains from an archaeal surface layer protein

Summary for 1L0Q

• Entry DOI: 10.2210/pdb1l0q/pdb
• Related: 1B4R 1IJQ
• Descriptor: Surface layer protein (2 entities in total)
• Functional Keywords: surface layer protein, slp, s-layer, 7-bladed beta-propeller, pkd superfamily, protein binding
• Biological source: Methanosarcina mazei
• Total number of polymer chains: 4
• Total formula weight: 163186.24

Authors

Jing, H.,Takagi, J.,Liu, J.-H.,Lindgren, S.,Zhang, R.-G.,Joachimiak, A.,Wang, J.-H.,Springer, T.A. (deposition date: 2002-02-12, release date: 2002-11-06, Last modification date: 2011-07-13)

Primary citation

Jing, H.,Takagi, J.,Liu, J.,Lindgren, S.,Zhang, R.,Joachimiak, A.,Wang, J.,Springer, T.
Archaeal Surface Layer Proteins Contain beta Propeller, PKD, and beta Helix Domains and Are Related to Metazoan Cell Surface Proteins.
Structure, 10:1453-1464, 2002

PubMed Abstract: The surface layer of archaeobacteria protects cells from extreme environments and, in Methanosarcina, may regulate cell adhesion. We identify three domain types that account for the complete architecture of numerous Methanosarcina surface layer proteins (SLPs). We solve the crystal structure for two of these domains, which correspond to the two N-terminal domains of an M. mazei SLP. One domain displays a unique, highly symmetrical, seven-bladed beta propeller fold, and the other belongs to the polycystic kidney disease (PKD) superfamily fold. The third domain is predicted to adopt a beta helix fold. These domains have homologs in metazoan cell surface proteins, suggesting remarkable relationships between domains in archaeal SLPs and metazoan cell surface proteins.

PubMed: 12377130
DOI: 10.1016/S0969-2126(02)00840-7

Experimental method

X-RAY DIFFRACTION (2.4 Å)