1KZQ

crystal structure of a parasite protein

1KZQ の概要

• エントリーDOI: 10.2210/pdb1kzq/pdb
• 分子名称: Major Surface Antigen P30 (2 entities in total)
• 機能のキーワード: sag1, major surface antigen, toxoplasma gondii, parasite invasion, mad, immune system
• 由来する生物種: Toxoplasma gondii
• 細胞内の位置: Parasitophorous vacuole: P13664
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 59659.75

構造登録者

He, X.,Grigg, M.E.,Boothroyd, J.C.,Garcia, K.C. (登録日: 2002-02-07, 公開日: 2002-07-31, 最終更新日: 2024-10-09)

主引用文献

He, X.L.,Grigg, M.E.,Boothroyd, J.C.,Garcia, K.C.
Structure of the immunodominant surface antigen from the Toxoplasma gondii SRS superfamily.
Nat.Struct.Biol., 9:606-611, 2002

PubMed Abstract: Toxoplasma gondii is a persistent protozoan parasite capable of infecting almost any warm-blooded vertebrate. The surface of Toxoplasma is coated with a family of developmentally regulated glycosylphosphatidylinositol (GPI)-linked proteins (SRSs), of which SAG1 is the prototypic member. SRS proteins mediate attachment to host cells and interface with the host immune response to regulate the virulence of the parasite. The 1.7 A structure of the immunodominant SAG1 antigen reveals a homodimeric configuration in which the dimeric interface is mediated by an extended beta-sheet that forms a deep groove lined with positively charged amino acids. This basic groove seems to be conserved among SRS proteins and potentially serves as a sulfated proteoglycan-binding site on target cell surfaces, thus rationalizing the promiscuous attachment properties of Toxoplasma to a broad range of host cell types.

PubMed: 12091874

実験手法

X-RAY DIFFRACTION (1.7 Å)