1KQ9

Human methionine aminopeptidase type II in complex with L-methionine

1KQ9 の概要

• エントリーDOI: 10.2210/pdb1kq9/pdb
• 関連するPDBエントリー: 1KQ0
• 分子名称: Methionine aminopeptidase 2, ZINC ION, METHIONINE, ... (5 entities in total)
• 機能のキーワード: central b-sheet and two pairs of a-helices, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 53339.70

構造登録者

Nonato, M.C.,Widom, J.,Clardy, J. (登録日: 2002-01-04, 公開日: 2003-12-09, 最終更新日: 2023-08-16)

主引用文献

Nonato, M.C.,Widom, J.,Clardy, J.
Human methionine aminopeptidase type 2 in complex with L- and D-methionine
Bioorg.Med.Chem.Lett., 16:2580-2583, 2006

PubMed Abstract: Human methionine aminopeptidase type 2 (hMetAP-2) was identified as the molecular target of anti-angiogenic agents such as fumagillin and its analogues. We describe here the crystal structure of hMetAP-2 in complex with l-methionine and d-methionine at 1.9 and 2.0A resolution, respectively. The comparison of the structure of the two complexes establishes the basis of enantiomer discrimination and provides some considerations for the design of selective MetAP-2 inhibitors.

PubMed: 16540317
DOI: 10.1016/j.bmcl.2006.02.047

実験手法

X-RAY DIFFRACTION (1.9 Å)