1KPT

STRUCTURE AND FUNCTION OF A VIRALLY ENCODED FUNGAL TOXIN FROM USTILAGO MAYDIS: A FUNGAL AND MAMMALIAN CALCIUM CHANNEL INHIBITOR

1KPT の概要

• エントリーDOI: 10.2210/pdb1kpt/pdb
• 分子名称: KP4 TOXIN (2 entities in total)
• 機能のキーワード: killer toxin, virally encoded, single subunit, alpha/beta family, left-handed crossover, ustilago maydis, fungal toxin, toxin
• 由来する生物種: Ustilago maydis
• 細胞内の位置: Secreted: Q90121
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22134.74

構造登録者

Gu, F.,Smith, T. (登録日: 1995-06-06, 公開日: 1995-10-31, 最終更新日: 2024-10-09)

主引用文献

Gu, F.,Khimani, A.,Rane, S.G.,Flurkey, W.H.,Bozarth, R.F.,Smith, T.J.
Structure and function of a virally encoded fungal toxin from Ustilago maydis: a fungal and mammalian Ca2+ channel inhibitor.
Structure, 3:805-814, 1995

PubMed Abstract: The P4 strain of the corn smut fungus, Ustilago maydis, secretes a fungal toxin, KP4, encoded by a fungal virus (UMV4) that persistently infects its cells. UMV4, unlike most other (non-fungal) viruses, does not spread to uninfected cells by release into the extracellular milieu during its normal life cycle and is thus dependent upon host survival for replication. In symbiosis with the host fungus, UMV4 encodes KP4 to kill other competitive strains of U. maydis, thereby promoting both host and virus survival. KP4 belongs to a family of fungal toxins and determining its structure should lead to a better understanding of the function and evolutionary origins of these toxins. Elucidation of the mechanism of toxin action could lead to new anti-fungal agents against human pathogens.

PubMed: 7582897
DOI: 10.1016/S0969-2126(01)00215-5

実験手法

X-RAY DIFFRACTION (1.75 Å)