1KPM

First Structural Evidence of a Specific Inhibition of Phospholipase A2 by Vitamin E and its Implications in Inflammation: Crystal Structure of the Complex Formed between Phospholipase A2 and Vitamin E at 1.8 A Resolution.

Replaces:  1FE7

Summary for 1KPM

• Entry DOI: 10.2210/pdb1kpm/pdb
• Related: 1CL5 1FB2 1FE7 1FV0 1JQ8 1JQ9
• Descriptor: Phospholipase A2, VITAMIN E, ACETIC ACID, ... (4 entities in total)
• Functional Keywords: phospholipase a2, daboia russelli pulchella, neurotoxic, inflammation, hydrolase
• Biological source: Daboia russellii pulchella
• Cellular location: Secreted : P59071
• Total number of polymer chains: 2
• Total formula weight: 27930.45

Authors

Chandra, V.,Jasti, J.,Kaur, P.,Betzel, C.,Srinivasan, A.,Singh, T.P. (deposition date: 2002-01-01, release date: 2002-07-10, Last modification date: 2023-08-16)

• Primary citation: Chandra, V.,Jasti, J.,Kaur, P.,Betzel, C.,Srinivasan, A.,Singh, T.P.; First Structural Evidence of a Specific Inhibition of Phospholipase A2 by alpha-Tocopherol (Vitamin E) and its Implications in Inflammation: Crystal Structure of the Complex Formed Between Phospholipase A2 and alpha-Tocopherol at 1.8 A Resolution; J.Mol.Biol., 320:215-222, 2002; PubMed: 12079380; DOI: 10.1016/S0022-2836(02)00473-4

Experimental method

X-RAY DIFFRACTION (1.8 Å)