1KPM

First Structural Evidence of a Specific Inhibition of Phospholipase A2 by Vitamin E and its Implications in Inflammation: Crystal Structure of the Complex Formed between Phospholipase A2 and Vitamin E at 1.8 A Resolution.

Replaces:  1FE7

Summary for 1KPM

Related1FE7 1FB2 1CL5 1JQ8 1JQ9 1FV0
DescriptorPhospholipase A2, VITAMIN E, ACETIC ACID, ... (4 entities in total)
Functional Keywordsphospholipase a2, daboia russelli pulchella, neurotoxic, inflammation, hydrolase
Biological sourceDaboia russellii pulchella
Cellular locationSecreted  P59071
Total number of polymer chains2
Total molecular weight27930.45
Authors
Chandra, V.,Jasti, J.,Kaur, P.,Betzel, C.,Srinivasan, A.,Singh, T.P. (deposition date: 2002-01-01, release date: 2002-07-10, Last modification date: 2017-10-11)
Primary citation
Chandra, V.,Jasti, J.,Kaur, P.,Betzel, C.,Srinivasan, A.,Singh, T.P.
First Structural Evidence of a Specific Inhibition of Phospholipase A2 by alpha-Tocopherol (Vitamin E) and its Implications in Inflammation: Crystal Structure of the Complex Formed Between Phospholipase A2 and alpha-Tocopherol at 1.8 A Resolution
J.Mol.Biol., 320:215-222, 2002
PubMed: 12079380 (PDB entries with the same primary citation)
DOI: 10.1016/S0022-2836(02)00473-4
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.8 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers220.4%2.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution