1KNK

Crystal Structure of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate Synthase (ispF) from E. coli involved in Mevalonate-Independent Isoprenoid Biosynthesis

Summary for 1KNK

• Entry DOI: 10.2210/pdb1knk/pdb
• Related: 1KNJ
• Descriptor: 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MANGANESE (II) ION (3 entities in total)
• Functional Keywords: isoprenoids, deoxyxylulose/methyl-erythritol-phosphate pathway, cyclodiphosphate, mep, ygbb, ispf, mecdp, 2-c-methyl-d-erythritol-2, 4-cyclodiphosphate synthase, metal binding protein
• Biological source: Escherichia coli
• Total number of polymer chains: 1
• Total formula weight: 16975.47

Authors

Richard, S.B.,Ferrer, J.L.,Bowman, M.E.,Lillo, A.M.,Tetzlaff, C.N.,Cane, D.E.,Noel, J.P. (deposition date: 2001-12-18, release date: 2002-06-18, Last modification date: 2023-08-16)

• Primary citation: Richard, S.B.,Ferrer, J.L.,Bowman, M.E.,Lillo, A.M.,Tetzlaff, C.N.,Cane, D.E.,Noel, J.P.; Structure and mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase. An enzyme in the mevalonate-independent isoprenoid biosynthetic pathway.; J.Biol.Chem., 277:8667-8672, 2002; PubMed: 11786530; DOI: 10.1074/jbc.C100739200

Experimental method

X-RAY DIFFRACTION (2.8 Å)