1KN3

Murine PEBP-2 (phosphatidylethanolamine-binding protein-2)

1KN3 の概要

• エントリーDOI: 10.2210/pdb1kn3/pdb
• 関連するPDBエントリー: 1A44 1BD9 1BEH 1FJJ 1FUX 1QOU
• 分子名称: Phosphatidylethanolamine Binding Protein-2 (2 entities in total)
• 機能のキーワード: phosphatidylethanolamine binding, raf-1 kinase inhibitor, cis-peptide, protein binding
• 由来する生物種: Mus musculus (house mouse)
• 細胞内の位置: Cytoplasm: Q8VIN1
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 20777.60

構造登録者

Simister, P.C.,Banfield, M.J.,Brady, R.L. (登録日: 2001-12-18, 公開日: 2002-06-12, 最終更新日: 2023-08-16)

主引用文献

Simister, P.C.,Banfield, M.J.,Brady, R.L.
The crystal structure of PEBP-2, a homologue of the PEBP/RKIP family.
Acta Crystallogr.,Sect.D, 58:1077-1080, 2002

PubMed Abstract: Proteins from the PEBP (phosphatidylethanolamine-binding protein) family have been identified in a wide variety of species and are thought to regulate a range of intracellular signalling cascades. The rat homologue (known as RKIP; Raf-1 kinase inhibitor protein) has been shown to negatively regulate the MAP kinase pathway through formation of inhibitory complexes with Raf-1 and MEK. The crystal structure of a new, murine member of the PEBP family, termed mPEBP-2, has been determined. On the basis of amino-acid homology, mPEBP-2 belongs to a distinct subset of the mammalian PEBP proteins. Nonetheless, mPEBP-2 is seen to be very similar in structure to other PEBP proteins from human, bovine and plant sources. Regions of distinctive sequence associated with the PEBP-2 subset are discussed with reference to this structure.

PubMed: 12037323
DOI: 10.1107/S090744490200522X

実験手法

X-RAY DIFFRACTION (1.8 Å)