1KLJ
Crystal structure of uninhibited factor VIIa
Summary for 1KLJ
Entry DOI | 10.2210/pdb1klj/pdb |
Related | 1KLI |
Descriptor | factor VIIa, CALCIUM ION, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | extrinsic coagulation pathway, serine protease activation, rational drug design, substrate-assisted catalysis, hydrolase |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P08709 P08709 |
Total number of polymer chains | 2 |
Total formula weight | 35815.94 |
Authors | Sichler, K.,Banner, D.,D'Arcy, A.,Hopfner, K.P.,Huber, R.,Bode, W.,Kresse, G.B.,Kopetzki, E.,Brandstetter, H. (deposition date: 2001-12-12, release date: 2002-10-09, Last modification date: 2023-08-16) |
Primary citation | Sichler, K.,Banner, D.W.,D'Arcy, A.,Hopfner, K.P.,Huber, R.,Bode, W.,Kresse, G.B.,Kopetzki, E.,Brandstetter, H. Crystal structures of uninhibited factor VIIa link its cofactor and substrate-assisted activation to specific interactions. J.Mol.Biol., 322:591-603, 2002 Cited by PubMed: 12225752DOI: 10.1016/S0022-2836(02)00747-7 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.44 Å) |
Structure validation
Download full validation report