1KLJ

Crystal structure of uninhibited factor VIIa

Summary for 1KLJ

• Entry DOI: 10.2210/pdb1klj/pdb
• Related: 1KLI
• Descriptor: factor VIIa, CALCIUM ION, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: extrinsic coagulation pathway, serine protease activation, rational drug design, substrate-assisted catalysis, hydrolase
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P08709 P08709
• Total number of polymer chains: 2
• Total formula weight: 35815.94

Authors

Sichler, K.,Banner, D.,D'Arcy, A.,Hopfner, K.P.,Huber, R.,Bode, W.,Kresse, G.B.,Kopetzki, E.,Brandstetter, H. (deposition date: 2001-12-12, release date: 2002-10-09, Last modification date: 2023-08-16)

• Primary citation: Sichler, K.,Banner, D.W.,D'Arcy, A.,Hopfner, K.P.,Huber, R.,Bode, W.,Kresse, G.B.,Kopetzki, E.,Brandstetter, H.; Crystal structures of uninhibited factor VIIa link its cofactor and substrate-assisted activation to specific interactions.; J.Mol.Biol., 322:591-603, 2002; PubMed: 12225752; DOI: 10.1016/S0022-2836(02)00747-7

Experimental method

X-RAY DIFFRACTION (2.44 Å)