1KEZ

Crystal Structure of the Macrocycle-forming Thioesterase Domain of Erythromycin Polyketide Synthase (DEBS TE)

1KEZ の概要

• エントリーDOI: 10.2210/pdb1kez/pdb
• 分子名称: ERYTHRONOLIDE SYNTHASE (2 entities in total)
• 機能のキーワード: polyketide synthase, 6-deoxyerythronolide synthase, modular polyketide synthase, thioesterase, 6-deb, te, debs, alpha, beta-hydrolase, macrocycle, transferase
• 由来する生物種: Saccharopolyspora erythraea
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 96338.30

構造登録者

Tsai, S.-C.,Miercke, L.J.W.,Krucinski, J.,Gokhale, R.,Chen, J.C.-H.,Foster, P.G.,Cane, D.E.,Khosla, C.,Stroud, R.M. (登録日: 2001-11-19, 公開日: 2002-01-09, 最終更新日: 2024-02-07)

• 主引用文献: Tsai, S.C.,Miercke, L.J.,Krucinski, J.,Gokhale, R.,Chen, J.C.,Foster, P.G.,Cane, D.E.,Khosla, C.,Stroud, R.M.; Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: versatility from a unique substrate channel.; Proc.Natl.Acad.Sci.USA, 98:14808-14813, 2001; PubMed: 11752428; DOI: 10.1073/pnas.011399198

実験手法

X-RAY DIFFRACTION (2.8 Å)