1KDE

NORTH-ATLANTIC OCEAN POUT ANTIFREEZE PROTEIN TYPE III ISOFORM HPLC12 MUTANT, NMR, 22 STRUCTURES

1KDE の概要

• エントリーDOI: 10.2210/pdb1kde/pdb
• 関連するPDBエントリー: 1KDF
• 分子名称: ANTIFREEZE PROTEIN TYPE III ISOFORM HPLC12 MUTANT (1 entity in total)
• 機能のキーワード: ice binding protein, thermal hysteresis protein, antifreeze protein, glycoprotein
• 由来する生物種: Macrozoarces americanus (ocean pout)
• 細胞内の位置: Secreted: P19614
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 7525.89

構造登録者

Sonnichsen, F.D.,Deluca, C.I.,Davies, P.L.,Sykes, B.D. (登録日: 1996-07-08, 公開日: 1997-04-21, 最終更新日: 2024-05-22)

主引用文献

Sonnichsen, F.D.,DeLuca, C.I.,Davies, P.L.,Sykes, B.D.
Refined solution structure of type III antifreeze protein: hydrophobic groups may be involved in the energetics of the protein-ice interaction.
Structure, 4:1325-1337, 1996

PubMed Abstract: Antifreeze proteins are found in certain fish inhabiting polar sea water. These proteins depress the freezing points of blood and body fluids below that of the surrounding sea water by binding to and inhibiting the growth of seed ice crystals. The proteins are believed to bind irreversibly to growing ice crystals in such a way as to change the curvature of the ice-water interface, leading to freezing point depression, but the mechanism of high-affinity ice binding is not yet fully understood.

PubMed: 8939756
DOI: 10.1016/S0969-2126(96)00140-2

実験手法

SOLUTION NMR