1K9I

Complex of DC-SIGN and GlcNAc2Man3

1K9I の概要

• エントリーDOI: 10.2210/pdb1k9i/pdb
• 関連するPDBエントリー: 1k9J
• 分子名称: mDC-SIGN1B type I isoform, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose, CALCIUM ION, ... (4 entities in total)
• 機能のキーワード: c-type lectin, protein carbohydrate complex, sugar binding protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 10
• 化学式量合計: 183933.05

構造登録者

Feinberg, H.,Mitchell, D.A.,Drickamer, K.,Weis, W.I. (登録日: 2001-10-29, 公開日: 2001-12-21, 最終更新日: 2020-07-29)

主引用文献

Feinberg, H.,Mitchell, D.A.,Drickamer, K.,Weis, W.I.
Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR.
Science, 294:2163-2166, 2001

PubMed Abstract: Dendritic cell specific intracellular adhesion molecule-3 (ICAM-3) grabbing nonintegrin (DC-SIGN), a C-type lectin present on the surface of dendritic cells, mediates the initial interaction of dendritic cells with T cells by binding to ICAM-3. DC-SIGN and DC-SIGNR, a related receptor found on the endothelium of liver sinusoids, placental capillaries, and lymph nodes, bind to oligosaccharides that are present on the envelope of human immunodeficiency virus (HIV), an interaction that strongly promotes viral infection of T cells. Crystal structures of carbohydrate-recognition domains of DC-SIGN and of DC-SIGNR bound to oligosaccharide, in combination with binding studies, reveal that these receptors selectively recognize endogenous high-mannose oligosaccharides and may represent a new avenue for developing HIV prophylactics.

PubMed: 11739956
DOI: 10.1126/science.1066371

実験手法

X-RAY DIFFRACTION (2.5 Å)