1K6V

LACK OF SYNERGY FOR INHIBITORS TARGETING A MULTI-DRUG RESISTANT HIV-1 PROTEASE

1K6V の概要

関連するPDBエントリー1K6C 1K6P 1K6T
分子名称POL polyprotein, ACETATE ION, N-[2-HYDROXY-1-INDANYL]-5-[(2-TERTIARYBUTYLAMINOCARBONYL)-4(BENZO[1,3]DIOXOL-5-YLMETHYL)-PIPERAZINO]-4-HYDROXY-2-(1-PHENYLETHYL)-PENTANAMIDE, ... (4 entities in total)
機能のキーワードindinavir, inhibitor recognition, drug resistance, hiv-1 protease, hydrolase
由来する生物種Human immunodeficiency virus 1
細胞内の位置Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential) P35963
ポリマー鎖数2
分子量合計22570.51
構造登録者
Schiffer, C.A. (登録日: 2001-10-17, 公開日: 2002-02-06, 最終更新日: 2011-07-13)
主引用文献
King, N.M.,Melnick, L.,Prabu-Jeyabalan, M.,Nalivaika, E.A.,Yang, S.S.,Gao, Y.,Nie, X.,Zepp, C.,Heefner, D.L.,Schiffer, C.A.
Lack of synergy for inhibitors targeting a multi-drug-resistant HIV-1 protease.
Protein Sci., 11:418-429, 2002
PubMed: 11790852 (主引用文献が同じPDBエントリー)
DOI: 10.1110/ps.2520102
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2 Å)
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構造検証レポート

ClashscoreRamachandran outliersSidechain outliers1200.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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