1K1T

Combining Mutations in HIV-1 Protease to Understand Mechanisms of Resistance

1K1T の概要

• エントリーDOI: 10.2210/pdb1k1t/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000349
• 分子名称: PROTEASE RETROPEPSIN, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: hiv-1 protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04587
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22354.32

構造登録者

Mahalingam, B.,Boross, P.,Wang, Y.-F.,Louis, J.M.,Fischer, C.,Tozser, J.,Harrison, R.W.,Weber, I.T. (登録日: 2001-09-25, 公開日: 2002-07-10, 最終更新日: 2024-02-07)

• 主引用文献: Mahalingam, B.,Boross, P.,Wang, Y.F.,Louis, J.M.,Fischer, C.C.,Tozser, J.,Harrison, R.W.,Weber, I.T.; Combining mutations in HIV-1 protease to understand mechanisms of resistance.; Proteins, 48:107-116, 2002; PubMed: 12012342; DOI: 10.1002/prot.10140

実験手法

X-RAY DIFFRACTION (1.2 Å)