1K12

Fucose Binding lectin

1K12 の概要

• エントリーDOI: 10.2210/pdb1k12/pdb
• 分子名称: LECTIN, alpha-L-fucopyranose, CALCIUM ION, ... (5 entities in total)
• 機能のキーワード: beta barrel, protein carbohydrate complex, sugar binding protein
• 由来する生物種: Anguilla anguilla (European eel)
• 細胞内の位置: Secreted (By similarity): Q7SIC1
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17148.33

構造登録者

Bianchet, M.A.,Odom, E.W.,Vasta, G.R.,Amzel, L.M. (登録日: 2001-09-23, 公開日: 2002-07-31, 最終更新日: 2024-11-13)

主引用文献

Bianchet, M.A.,Odom, E.W.,Vasta, G.R.,Amzel, L.M.
A novel fucose recognition fold involved in innate immunity.
Nat.Struct.Biol., 9:628-634, 2002

PubMed Abstract: Anguilla anguilla agglutinin (AAA), a fucolectin found in the serum of European eel, participates in the recognition of bacterial liposaccharides by the animal innate immunity system. Because AAA specifically recognizes fucosylated terminals of H and Lewis (a) blood groups, it has been used extensively as a reagent in blood typing and histochemistry. AAA contains a newly discovered carbohydrate recognition domain present in proteins of organisms ranging from bacteria to vertebrates. The crystal structure of the complex of AAA with alpha-L-fucose characterizes the novel fold of this entire lectin family, identifying the residues that provide the structural determinants of oligosaccharide specificity. Modification of these residues explains how the different isoforms in serum can provide a diverse pathogen-specific recognition.

PubMed: 12091873

実験手法

X-RAY DIFFRACTION (1.9 Å)