1JYS

Crystal Structure of E. coli MTA/AdoHcy Nucleosidase

1JYS の概要

• エントリーDOI: 10.2210/pdb1jys/pdb
• 分子名称: MTA/SAH nucleosidase, ADENINE (3 entities in total)
• 機能のキーワード: mixed alpha/beta, dimer, hydrolase
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 51246.50

構造登録者

Lee, J.E.,Cornell, K.A.,Riscoe, M.K.,Howell, P.L. (登録日: 2001-09-13, 公開日: 2002-10-01, 最終更新日: 2024-02-07)

主引用文献

Lee, J.E.,Cornell, K.A.,Riscoe, M.K.,Howell, P.L.
Structure of E. coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase reveals similarity to the purine nucleoside phosphorylases.
Structure, 9:941-953, 2001

PubMed Abstract: 5'-methylthioadenosine/S-adenosyl-homocysteine (MTA/AdoHcy) nucleosidase catalyzes the irreversible cleavage of 5'-methylthioadenosine and S-adenosylhomocysteine to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. While this enzyme is crucial for the metabolism of AdoHcy and MTA nucleosides in many prokaryotic and lower eukaryotic organisms, it is absent in mammalian cells. This metabolic difference represents an exploitable target for rational drug design.

PubMed: 11591349
DOI: 10.1016/S0969-2126(01)00656-6

実験手法

X-RAY DIFFRACTION (1.9 Å)