1JUX

1.6A Resolution Crystal Structures of the DNA Octamers d(IUATATAC) and d(ITITACAC):Binding of Two Distamycin Drugs Side-by-Side

Summary for 1JUX

• Entry DOI: 10.2210/pdb1jux/pdb
• Related: 1JUZ
• Descriptor: 5'-D(*IP*TP*IP*TP*AP*CP*AP*C)-3', DISTAMYCIN A (3 entities in total)
• Functional Keywords: dna, octamer, distamycin, side-by-side
• Total number of polymer chains: 1
• Total formula weight: 2878.10

Authors

Deng, J.,Pan, B.,Sundaralingam, M. (deposition date: 2001-08-28, release date: 2004-01-27, Last modification date: 2024-02-07)

Primary citation

Deng, J.,Pan, B.,Sundaralingam, M.
Structure of d(ITITACAC) complexed with distamycin at 1.6 A resolution.
Acta Crystallogr.,Sect.D, 59:2342-2344, 2003

PubMed Abstract: The crystal structure of the DNA octamer d(ITITACAC)(2) complexed with distamycin has been determined at 1.6 A resolution and refined to a final R(work) and R(free) of 17.0 and 20.7%, respectively. Two molecules of distamycin bind to the DNA duplex in an antiparallel side-by-side fashion. Each drug molecule covers five base pairs of the DNA duplex, with its amide groups hydrogen-bonding to bases in the proximal DNA strand. These two antiparallel drug molecules are stacked together with the pyrrole rings of one molecule stacking against the amide groups of the other. The present structure emphasizes the features of alternating DNA octamers in interaction with distamycin.

PubMed: 14646114
DOI: 10.1107/S0907444903020730

Experimental method

X-RAY DIFFRACTION (1.6 Å)