1JUX

1.6A Resolution Crystal Structures of the DNA Octamers d(IUATATAC) and d(ITITACAC):Binding of Two Distamycin Drugs Side-by-Side

1JUX の概要

• エントリーDOI: 10.2210/pdb1jux/pdb
• 関連するPDBエントリー: 1JUZ
• 分子名称: 5'-D(*IP*TP*IP*TP*AP*CP*AP*C)-3', DISTAMYCIN A (3 entities in total)
• 機能のキーワード: dna, octamer, distamycin, side-by-side
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 2878.10

構造登録者

Deng, J.,Pan, B.,Sundaralingam, M. (登録日: 2001-08-28, 公開日: 2004-01-27, 最終更新日: 2024-02-07)

主引用文献

Deng, J.,Pan, B.,Sundaralingam, M.
Structure of d(ITITACAC) complexed with distamycin at 1.6 A resolution.
Acta Crystallogr.,Sect.D, 59:2342-2344, 2003

PubMed Abstract: The crystal structure of the DNA octamer d(ITITACAC)(2) complexed with distamycin has been determined at 1.6 A resolution and refined to a final R(work) and R(free) of 17.0 and 20.7%, respectively. Two molecules of distamycin bind to the DNA duplex in an antiparallel side-by-side fashion. Each drug molecule covers five base pairs of the DNA duplex, with its amide groups hydrogen-bonding to bases in the proximal DNA strand. These two antiparallel drug molecules are stacked together with the pyrrole rings of one molecule stacking against the amide groups of the other. The present structure emphasizes the features of alternating DNA octamers in interaction with distamycin.

PubMed: 14646114
DOI: 10.1107/S0907444903020730

実験手法

X-RAY DIFFRACTION (1.6 Å)