1JUT

E. coli Thymidylate Synthase Bound to dUMP and LY338529, A Pyrrolo(2,3-d)pyrimidine-based Antifolate

1JUT の概要

• エントリーDOI: 10.2210/pdb1jut/pdb
• 関連するPDBエントリー: 1JTQ 1JTU 1JU6 1JUJ
• 分子名称: THYMIDYLATE SYNTHASE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-3-METHYL-BUTYRIC ACID, ... (4 entities in total)
• 機能のキーワード: antifolate, dtmp synthesis, cancer, drug resistance, transferase
• 由来する生物種: Escherichia coli
• 細胞内の位置: Cytoplasm: P0A884
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 62530.55

構造登録者

Sayre, P.H.,Finer-Moore, J.S.,Fritz, T.A.,Biermann, D.,Gates, S.B.,MacKellar, W.C.,Patel, V.F.,Stroud, R.M. (登録日: 2001-08-27, 公開日: 2001-09-19, 最終更新日: 2023-08-16)

• 主引用文献: Sayre, P.H.,Finer-Moore, J.S.,Fritz, T.A.,Biermann, D.,Gates, S.B.,MacKellar, W.C.,Patel, V.F.,Stroud, R.M.; Multi-targeted antifolates aimed at avoiding drug resistance form covalent closed inhibitory complexes with human and Escherichia coli thymidylate synthases.; J.Mol.Biol., 313:813-829, 2001; PubMed: 11697906; DOI: 10.1006/jmbi.2001.5074

実験手法

X-RAY DIFFRACTION (2.7 Å)