1JU6

Human Thymidylate Synthase Complex with dUMP and LY231514, A Pyrrolo(2,3-d)pyrimidine-based Antifolate

Summary for 1JU6

Entry DOI	10.2210/pdb1ju6/pdb
Related	1JTQ 1JTU 1JUJ 1JUT
Descriptor	THYMIDYLATE SYNTHASE, PHOSPHATE ION, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, ... (5 entities in total)
Functional Keywords	antifolate, dtmp synthesis, drug resistance, cancer, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	145976.78
Authors	Sayre, P.H.,Finer-Moore, J.S.,Fritz, T.A.,Biermann, D.,Gates, S.B.,MacKellar, W.C.,Patel, V.F.,Stroud, R.M. (deposition date: 2001-08-23, release date: 2001-09-19, Last modification date: 2024-04-03)
Primary citation	Sayre, P.H.,Finer-Moore, J.S.,Fritz, T.A.,Biermann, D.,Gates, S.B.,MacKellar, W.C.,Patel, V.F.,Stroud, R.M. Multi-targeted antifolates aimed at avoiding drug resistance form covalent closed inhibitory complexes with human and Escherichia coli thymidylate synthases. J.Mol.Biol., 313:813-829, 2001 Cited by PubMed: 11697906 DOI: 10.1006/jmbi.2001.5074 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.89 Å)

Structure validation