1JU6

Human Thymidylate Synthase Complex with dUMP and LY231514, A Pyrrolo(2,3-d)pyrimidine-based Antifolate

1JU6 の概要

• エントリーDOI: 10.2210/pdb1ju6/pdb
• 関連するPDBエントリー: 1JTQ 1JTU 1JUJ 1JUT
• 分子名称: THYMIDYLATE SYNTHASE, PHOSPHATE ION, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, ... (5 entities in total)
• 機能のキーワード: antifolate, dtmp synthesis, drug resistance, cancer, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 145976.78

構造登録者

Sayre, P.H.,Finer-Moore, J.S.,Fritz, T.A.,Biermann, D.,Gates, S.B.,MacKellar, W.C.,Patel, V.F.,Stroud, R.M. (登録日: 2001-08-23, 公開日: 2001-09-19, 最終更新日: 2024-04-03)

• 主引用文献: Sayre, P.H.,Finer-Moore, J.S.,Fritz, T.A.,Biermann, D.,Gates, S.B.,MacKellar, W.C.,Patel, V.F.,Stroud, R.M.; Multi-targeted antifolates aimed at avoiding drug resistance form covalent closed inhibitory complexes with human and Escherichia coli thymidylate synthases.; J.Mol.Biol., 313:813-829, 2001; PubMed: 11697906; DOI: 10.1006/jmbi.2001.5074

実験手法

X-RAY DIFFRACTION (2.89 Å)