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1JSM

STRUCTURE OF H5 AVIAN HAEMAGGLUTININ

Summary for 1JSM
Entry DOI10.2210/pdb1jsm/pdb
Related1JSD 1JSH 1JSI 1JSN 1JSO
DescriptorHAEMAGGLUTININ (HA1 CHAIN), HAEMAGGLUTININ (HA2 CHAIN), 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywordsinfluenza, receptor complex, fusion protein, viral protein
Biological sourceInfluenza A virus
More
Total number of polymer chains2
Total formula weight58285.87
Authors
Ha, Y.,Stevens, D.J.,Skehel, J.J.,Wiley, D.C. (deposition date: 2001-08-17, release date: 2001-09-26, Last modification date: 2024-11-06)
Primary citationHa, Y.,Stevens, D.J.,Skehel, J.J.,Wiley, D.C.
H5 avian and H9 swine influenza virus haemagglutinin structures: possible origin of influenza subtypes.
EMBO J., 21:865-875, 2002
Cited by
PubMed Abstract: There are 15 subtypes of influenza A virus (H1-H15), all of which are found in avian species. Three caused pandemics in the last century: H1 in 1918 (and 1977), H2 in 1957 and H3 in 1968. In 1997, an H5 avian virus and in 1999 an H9 virus caused outbreaks of respiratory disease in Hong Kong. We have determined the three-dimensional structures of the haemagglutinins (HAs) from H5 avian and H9 swine viruses closely related to the viruses isolated from humans in Hong Kong. We have compared them with known structures of the H3 HA from the virus that caused the 1968 H3 pandemic and of the HA--esterase--fusion (HEF) glycoprotein from an influenza C virus. Structure and sequence comparisons suggest that HA subtypes may have originated by diversification of properties that affected the metastability of HAs required for their membrane fusion activities in viral infection.
PubMed: 11867515
DOI: 10.1093/emboj/21.5.865
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

239149

数据于2025-07-23公开中

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