1JSG

CRYSTAL STRUCTURE OF P14TCL1, AN ONCOGENE PRODUCT INVOLVED IN T-CELL PROLYMPHOCYTIC LEUKEMIA, REVEALS A NOVEL B-BARREL TOPOLOGY

Summary for 1JSG

• Entry DOI: 10.2210/pdb1jsg/pdb
• Descriptor: ONCOGENE PRODUCT P14TCL1 (2 entities in total)
• Functional Keywords: proto-oncogene, cl1 gene, t cell leukemia, oncoprotein, microsome
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm (By similarity): P56279
• Total number of polymer chains: 1
• Total formula weight: 13475.54

Authors

Hoh, F.,Yang, Y.-S.,Guignard, L.,Padilla, A.,Stern, R.-H.,Lhoste, J.-M.,Van Tilbeurgh, H. (deposition date: 1997-12-03, release date: 1998-03-18, Last modification date: 2024-02-07)

Primary citation

Hoh, F.,Yang, Y.S.,Guignard, L.,Padilla, A.,Stern, M.H.,Lhoste, J.M.,van Tilbeurgh, H.
Crystal structure of p14TCL1, an oncogene product involved in T-cell prolymphocytic leukemia, reveals a novel beta-barrel topology.
Structure, 6:147-155, 1998

PubMed Abstract: Chromosome rearrangements are frequently involved in the generation of hematopoietic tumors. One type of T-cell leukemia, T-cell prolymphocytic leukemia, is consistently associated with chromosome rearrangements characterized by the juxtaposition of the TCRA locus on chromosome 14q11 and either the TCL1 gene on 14q32.1 or the MTCP1 gene on Xq28. The TCL1 gene is preferentially expressed in cells of early lymphoid lineage; its product is a 14 kDa protein (p14TCL1), expressed in the cytoplasm. p14TCL1 has strong sequence similarity with one product of the MTCP1 gene, p13MTCP1 (41% identical and 61% similar). The functions of the TCL1 and MTCP1 genes are not known yet. They have no sequence similarity to any other published sequence, including those of well-documented oncogene families responsible for leukemia. In order to gain a more fundamental insight into the role of this particular class of oncogenes, we have determined the three-dimensional structure of p14TCL1.

PubMed: 9519406
DOI: 10.1016/S0969-2126(98)00017-3

Experimental method

X-RAY DIFFRACTION (2.5 Å)