1JSG

CRYSTAL STRUCTURE OF P14TCL1, AN ONCOGENE PRODUCT INVOLVED IN T-CELL PROLYMPHOCYTIC LEUKEMIA, REVEALS A NOVEL B-BARREL TOPOLOGY

1JSG の概要

• エントリーDOI: 10.2210/pdb1jsg/pdb
• 分子名称: ONCOGENE PRODUCT P14TCL1 (2 entities in total)
• 機能のキーワード: proto-oncogene, cl1 gene, t cell leukemia, oncoprotein, microsome
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm (By similarity): P56279
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 13475.54

構造登録者

Hoh, F.,Yang, Y.-S.,Guignard, L.,Padilla, A.,Stern, R.-H.,Lhoste, J.-M.,Van Tilbeurgh, H. (登録日: 1997-12-03, 公開日: 1998-03-18, 最終更新日: 2024-02-07)

主引用文献

Hoh, F.,Yang, Y.S.,Guignard, L.,Padilla, A.,Stern, M.H.,Lhoste, J.M.,van Tilbeurgh, H.
Crystal structure of p14TCL1, an oncogene product involved in T-cell prolymphocytic leukemia, reveals a novel beta-barrel topology.
Structure, 6:147-155, 1998

PubMed Abstract: Chromosome rearrangements are frequently involved in the generation of hematopoietic tumors. One type of T-cell leukemia, T-cell prolymphocytic leukemia, is consistently associated with chromosome rearrangements characterized by the juxtaposition of the TCRA locus on chromosome 14q11 and either the TCL1 gene on 14q32.1 or the MTCP1 gene on Xq28. The TCL1 gene is preferentially expressed in cells of early lymphoid lineage; its product is a 14 kDa protein (p14TCL1), expressed in the cytoplasm. p14TCL1 has strong sequence similarity with one product of the MTCP1 gene, p13MTCP1 (41% identical and 61% similar). The functions of the TCL1 and MTCP1 genes are not known yet. They have no sequence similarity to any other published sequence, including those of well-documented oncogene families responsible for leukemia. In order to gain a more fundamental insight into the role of this particular class of oncogenes, we have determined the three-dimensional structure of p14TCL1.

PubMed: 9519406
DOI: 10.1016/S0969-2126(98)00017-3

実験手法

X-RAY DIFFRACTION (2.5 Å)