1JNX

Crystal structure of the BRCT repeat region from the breast cancer associated protein, BRCA1

1JNX の概要

• エントリーDOI: 10.2210/pdb1jnx/pdb
• 関連するPDBエントリー: 1CDZ 1IMO 1IN1
• 分子名称: BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN, NICKEL (II) ION (3 entities in total)
• 機能のキーワード: brct, cancer, gene expression, gene regulation
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus . Isoform 3: Cytoplasm. Isoform 5: Cytoplasm : P38398
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24589.93

構造登録者

Williams, R.S.,Green, R.,Glover, J.N.M. (登録日: 2001-07-26, 公開日: 2001-09-21, 最終更新日: 2024-02-07)

主引用文献

Williams, R.S.,Green, R.,Glover, J.N.
Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1.
Nat.Struct.Biol., 8:838-842, 2001

PubMed Abstract: The C-terminal BRCT region of BRCA1 is essential for its DNA repair, transcriptional regulation and tumor suppressor functions. Here we determine the crystal structure of the BRCT domain of human BRCA1 at 2.5 A resolution. The domain contains two BRCT repeats that adopt similar structures and are packed together in a head-to-tail arrangement. Cancer-causing missense mutations occur at the interface between the two repeats and destabilize the structure. The manner by which the two BRCT repeats interact in BRCA1 may represent a general mode of interaction between homologous domains within proteins that interact to regulate the cellular response to DNA damage. The structure provides a basis to predict the structural consequences of uncharacterized BRCA1 mutations.

PubMed: 11573086
DOI: 10.1038/nsb1001-838

実験手法

X-RAY DIFFRACTION (2.5 Å)