1JNP

Crystal Structure of Murine Tcl1 at 2.5 Resolution

1JNP の概要

• エントリーDOI: 10.2210/pdb1jnp/pdb
• 分子名称: T-CELL LEUKEMIA/LYMPHOMA PROTEIN 1A (2 entities in total)
• 機能のキーワード: beta barrel, dimer, immune system
• 由来する生物種: Mus musculus (house mouse)
• 細胞内の位置: Cytoplasm : P56280
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28196.07

構造登録者

Petock, J.M.,Torshin, I.Y.,Wang, Y.F.,DuBois, G.C.,Croce, C.M.,Harrison, R.W.,Weber, I.T. (登録日: 2001-07-24, 公開日: 2001-11-07, 最終更新日: 2024-02-07)

主引用文献

Petock, J.M.,Torshin, I.Y.,Wang, Y.F.,Du Bois, G.C.,Croce, C.M.,Harrison, R.W.,Weber, I.T.
Structure of murine Tcl1 at 2.5 A resolution and implications for the TCL oncogene family.
Acta Crystallogr.,Sect.D, 57:1545-1551, 2001

PubMed Abstract: Tcl1 and Mtcp1, members of the Tcl1 family, are implicated in T-cell prolymphocytic leukemia. The crystal structure of a dimer of murine Tcl1 has been determined at 2.5 A resolution with an R factor of 0.225. Murine Tcl1, human Tcl1 and Mtcp1 share very similar subunit structures, with RMS differences of 0.6 and 1.4 A for C(alpha) atoms, respectively, while the sequences share 50 and 36% identity, respectively. These structures fold into an eight-stranded beta-barrel of unique topology and high internal symmetry of 1.1-1.3 A for the two halves of human and murine Tcl1 and 1.7 A for Mtcp1, despite the low 12-13% sequence identity. The molecular surfaces of all three structures showed a common planar region which is likely to be involved in protein-protein interactions.

PubMed: 11679718
DOI: 10.1107/S090744490101352X

実験手法

X-RAY DIFFRACTION (2.5 Å)