1JKX

Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase

1JKX の概要

• エントリーDOI: 10.2210/pdb1jkx/pdb
• 分子名称: PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE, N-[5'-O-PHOSPHONO-RIBOFURANOSYL]-2-[2-HYDROXY-2-[4-[GLUTAMIC ACID]-N-CARBONYLPHENYL]-3-[2-AMINO-4-HYDROXY-QUINAZOLIN-6-YL]-PROPANYLAMINO]-ACETAMIDE (3 entities in total)
• 機能のキーワード: purine biosynthesis, anti-cancer agent, enzyme-assembled multisubstrate adduct inhibitor complex, transferase
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 96075.50

構造登録者

Greasley, S.E.,Marsilje, T.H.,Cai, H.,Baker, S.,Benkovic, S.J.,Boger, D.L.,Wilson, I.A. (登録日: 2001-07-13, 公開日: 2001-11-30, 最終更新日: 2024-03-13)

• 主引用文献: Greasley, S.E.,Marsilje, T.H.,Cai, H.,Baker, S.,Benkovic, S.J.,Boger, D.L.,Wilson, I.A.; Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase.; Biochemistry, 40:13538-13547, 2001; PubMed: 11695901; DOI: 10.1021/bi011482+

実験手法

X-RAY DIFFRACTION (1.6 Å)