1JII

Crystal structure of S. aureus TyrRS in complex with SB-219383

1JII の概要

• エントリーDOI: 10.2210/pdb1jii/pdb
• 関連するPDBエントリー: 1JIJ 1JIK 1JIL
• 分子名称: tyrosyl-tRNA synthetase, [2-AMINO-3-(4-HYDROXY-PHENYL)-PROPIONYLAMINO]- (2,4,5,8-TETRAHYDROXY-7-OXA-2-AZA-BICYCLO[3.2.1]OCT-3-YL)- ACETIC ACID (2 entities in total)
• 機能のキーワード: tyrosyl-trna synthetase, staphylococcus aureus, truncation, structure based inhibitor design, ligase
• 由来する生物種: Staphylococcus aureus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 48068.83

構造登録者

Qiu, X.,Janson, C.A.,Smith, W.W.,Jarvest, R.L. (登録日: 2001-07-02, 公開日: 2001-10-26, 最終更新日: 2024-04-03)

• 主引用文献: Qiu, X.,Janson, C.A.,Smith, W.W.,Green, S.M.,McDevitt, P.,Johanson, K.,Carter, P.,Hibbs, M.,Lewis, C.,Chalker, A.,Fosberry, A.,Lalonde, J.,Berge, J.,Brown, P.,Houge-Frydrych, C.S.,Jarvest, R.L.; Crystal structure of Staphylococcus aureus tyrosyl-tRNA synthetase in complex with a class of potent and specific inhibitors.; Protein Sci., 10:2008-2016, 2001; PubMed: 11567092; DOI: 10.1110/ps.18001

実験手法

X-RAY DIFFRACTION (3.2 Å)