1JI7

Crystal Structure of TEL SAM Polymer

1JI7 の概要

• エントリーDOI: 10.2210/pdb1ji7/pdb
• 関連するPDBエントリー: 1BQV
• 分子名称: ETS-RELATED PROTEIN TEL1, SULFATE ION (3 entities in total)
• 機能のキーワード: helical polymer, transcription
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: P41212
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 33327.74

構造登録者

Kim, C.A.,Phillips, M.L.,Kim, W.,Gingery, M.,Tran, H.H.,Robinson, M.A.,Faham, S.,Bowie, J.U. (登録日: 2001-06-29, 公開日: 2002-07-03, 最終更新日: 2024-11-20)

主引用文献

Kim, C.A.,Phillips, M.L.,Kim, W.,Gingery, M.,Tran, H.H.,Robinson, M.A.,Faham, S.,Bowie, J.U.
Polymerization of the SAM domain of TEL in leukemogenesis and transcriptional repression.
EMBO J., 20:4173-4182, 2001

PubMed Abstract: TEL is a transcriptional repressor that is a frequent target of chromosomal translocations in a large number of hematalogical malignancies. These rearrangements fuse a potent oligomerization module, the SAM domain of TEL, to a variety of tyrosine kinases or transcriptional regulatory proteins. The self-associating property of TEL-SAM is essential for cell transformation in many, if not all of these diseases. Here we show that the TEL-SAM domain forms a helical, head-to-tail polymeric structure held together by strong intermolecular contacts, providing the first clear demonstration that SAM domains can polymerize. Our results also suggest a mechanism by which SAM domains could mediate the spreading of transcriptional repression complexes along the chromosome.

PubMed: 11483520
DOI: 10.1093/emboj/20.15.4173

実験手法

X-RAY DIFFRACTION (1.45 Å)