1JI4

NAP protein from helicobacter pylori

1JI4 の概要

• エントリーDOI: 10.2210/pdb1ji4/pdb
• 関連するPDBエントリー: 1DPS 1QGH
• 分子名称: NEUTROPHIL-ACTIVATING PROTEIN A, FE (III) ION, UNKNOWN ATOM OR ION, ... (5 entities in total)
• 機能のキーワード: dodecamer, four-helix bundle, metal transport
• 由来する生物種: Helicobacter pylori
• 細胞内の位置: Cytoplasm: P43313
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 205612.98

構造登録者

Zanotti, G.,Papinutto, E.,Dundon, W.G.,Battistutta, R.,Seveso, M.,Del Giudice, G.,Rappuoli, R.,Montecucco, C. (登録日: 2001-06-29, 公開日: 2002-10-09, 最終更新日: 2023-08-16)

主引用文献

Zanotti, G.,Papinutto, E.,Dundon, W.G.,Battistutta, R.,Seveso, M.,Del Giudice, G.,Rappuoli, R.,Montecucco, C.
Structure of the Neutrophil-activating Protein from Helicobacter pylori
J.Mol.Biol., 323:125-130, 2002

PubMed Abstract: Helicobacter pylori is a major human pathogen associated with severe gastroduodenal diseases, including ulcers and cancers. An H.pylori protein that is highly immunogenic in humans and mice has been identified recently. This protein has been termed HP-NAP, due to its ability of activating neutrophils. In order to achieve a molecular understanding of its unique immunogenic and pro-inflammatory properties, we have determined its three-dimensional structure. Its quaternary structure is similar to that of the dodecameric bacterial ferritins (Dps-like family), but it has a different surface potential charge distribution. This is due to the presence of a large number of positively charged residues, which could well account for its unique ability in activating human leukocytes.

PubMed: 12368104
DOI: 10.1016/S0022-2836(02)00879-3

実験手法

X-RAY DIFFRACTION (2.52 Å)