1JD0

CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN CARBONIC ANHYDRASE XII COMPLEXED WITH ACETAZOLAMIDE

1JD0 の概要

• エントリーDOI: 10.2210/pdb1jd0/pdb
• 分子名称: CARBONIC ANHYDRASE XII, ZINC ION, 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, ... (4 entities in total)
• 機能のキーワード: extracellular domain, human carbonic anhydrase xii, bitopic membrane protein, type i membrane protein, lyase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: O43570
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 60289.71

構造登録者

Whittington, D.A.,Waheed, A.,Ulmasov, B.,Shah, G.N.,Grubb, J.H.,Sly, W.S.,Christianson, D.W. (登録日: 2001-06-11, 公開日: 2001-08-17, 最終更新日: 2011-11-16)

• 主引用文献: Whittington, D.A.,Waheed, A.,Ulmasov, B.,Shah, G.N.,Grubb, J.H.,Sly, W.S.,Christianson, D.W.; Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells.; Proc.Natl.Acad.Sci.USA, 98:9545-9550, 2001; PubMed: 11493685; DOI: 10.1073/pnas.161301298

実験手法

X-RAY DIFFRACTION (1.5 Å)