1J7X

CRYSTAL STRUCTURE OF A FUNCTIONAL UNIT OF INTERPHOTORECEPTOR RETINOID-BINDING PROTEIN (IRBP)

1J7X の概要

• エントリーDOI: 10.2210/pdb1j7x/pdb
• 分子名称: INTERPHOTORECEPTOR RETINOID-BINDING PROTEIN (2 entities in total)
• 機能のキーワード: beta beta alpha spiral, transport protein
• 由来する生物種: Xenopus laevis (African clawed frog)
• 細胞内の位置: Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix: Q7SZI7
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33510.38

構造登録者

Loew, A.,Gonzalez-Fernandez, F. (登録日: 2001-05-19, 公開日: 2002-02-20, 最終更新日: 2024-11-13)

主引用文献

Loew, A.,Gonzalez-Fernandez, F.
Crystal structure of the functional unit of interphotoreceptor retinoid binding protein.
Structure, 10:43-49, 2002

PubMed Abstract: Interphotoreceptor retinoid binding protein (IRBP), the major soluble component of the interphotoreceptor matrix, is critical to the function, integrity, and development of the vertebrate retina. Although its role is poorly understood, IRBP has been thought to protect 11-cis retinal and all-trans retinol while facilitating their exchange between the photoreceptors and retinal-pigmented epithelium. We determined the X-ray structure of one of the functional units, or modules, of Xenopus laevis IRBP to 1.8 A resolution by multiwavelength anomalous dispersion. The monomeric protein consists of two domains separated by a hydrophobic ligand binding site. A structural homology to the recently solved photosystem II D1 C-terminal-processing protease and the enoyl-CoA isomerase/hydratase family suggests the utility of a common fold used in diverse settings, ranging from proteolysis to fatty acid isomerization to retinoid transport.

PubMed: 11796109
DOI: 10.1016/S0969-2126(01)00698-0

実験手法

X-RAY DIFFRACTION (1.8 Å)