1J3J

Double mutant (C59R+S108N) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with pyrimethamine, NADPH, and dUMP

1J3J の概要

• エントリーDOI: 10.2210/pdb1j3j/pdb
• 関連するPDBエントリー: 1J3I 1J3K
• 分子名称: Bifunctional dihydrofolate reductase-thymidylate synthase, 5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (6 entities in total)
• 機能のキーワード: bifunctional, oxidoreductase, transferase
• 由来する生物種: Plasmodium falciparum (malaria parasite P. falciparum); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 146459.03

構造登録者

Yuvaniyama, J.,Chitnumsub, P.,Kamchonwongpaisan, S.,Vanichtanankul, J.,Sirawaraporn, W.,Taylor, P.,Walkinshaw, M.,Yuthavong, Y. (登録日: 2003-02-03, 公開日: 2003-05-06, 最終更新日: 2023-12-27)

• 主引用文献: Yuvaniyama, J.,Chitnumsub, P.,Kamchonwongpaisan, S.,Vanichtanankul, J.,Sirawaraporn, W.,Taylor, P.,Walkinshaw, M.D.,Yuthavong, Y.; Insights into antifolate resistance from malarial DHFR-TS structures.; NAT.STRUCT.BIOL., 10:357-365, 2003; PubMed: 12704428; DOI: 10.1038/nsb921

実験手法

X-RAY DIFFRACTION (2.3 Å)