1J1A

PANCREATIC SECRETORY PHOSPHOLIPASE A2 (IIa) WITH ANTI-INFLAMMATORY ACTIVITY

1J1A の概要

• エントリーDOI: 10.2210/pdb1j1a/pdb
• 分子名称: Phospholipase A2, CALCIUM ION, (S)-5-(4-BENZYLOXY-PHENYL)-4-(7-PHENYL-HEPTANOYLAMINO)-PENTANOIC ACID, ... (4 entities in total)
• 機能のキーワード: medicinal chemistry, enzyme inhibitor, structure-activity relationships, inflammation, hydrolase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Peripheral membrane protein: P14555
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 29025.60

構造登録者

Hansford, K.A.,Reid, R.C.,Clark, C.I.,Tyndall, J.D.A.,Whitehouse, M.W.,Guthrie, T.,McGeary, R.P.,Schafer, K.,Martin, J.L.,Fairlie, D.P. (登録日: 2002-12-03, 公開日: 2003-03-18, 最終更新日: 2023-10-25)

• 主引用文献: Hansford, K.A.,Reid, R.C.,Clark, C.I.,Tyndall, J.D.A.,Whitehouse, M.W.,Guthrie, T.,McGeary, R.P.,Schafer, K.,Martin, J.L.,Fairlie, D.P.; D-Tyrosine as a Chiral Precusor to Potent Inhibitors of Human Nonpancreatic Secretory Phospholipase A2 (IIa) with Antiinflammatory Activity; Chembiochem, 4:181-185, 2003; PubMed: 12616631; DOI: 10.1002/cbic.200390029

実験手法

X-RAY DIFFRACTION (2.2 Å)