1IVP

THE CRYSTALLOGRAPHIC STRUCTURE OF THE PROTEASE FROM HUMAN IMMUNODEFICIENCY VIRUS TYPE 2 WITH TWO SYNTHETIC PEPTIDIC TRANSITION STATE ANALOG INHIBITORS

1IVP の概要

• エントリーDOI: 10.2210/pdb1ivp/pdb
• 関連するPDBエントリー: 1IVQ
• 関連するBIRD辞書のPRD_ID: PRD_000403
• 分子名称: HIV-2 PROTEASE, 4-[(2R)-3-{[(1S,2S,3R,4S)-1-(cyclohexylmethyl)-2,3-dihydroxy-5-methyl-4-({(1S,2R)-2-methyl-1-[(pyridin-2-ylmethyl)carba moyl]butyl}carbamoyl)hexyl]amino}-2-{[(naphthalen-1-yloxy)acetyl]amino}-3-oxopropyl]-1H-imidazol-3-ium (3 entities in total)
• 機能のキーワード: acid proteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus 2
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04584
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22237.65

構造登録者

Mulichak, A.M.,Watenpaugh, K.D. (登録日: 1993-03-18, 公開日: 1993-07-15, 最終更新日: 2024-02-07)

• 主引用文献: Mulichak, A.M.,Hui, J.O.,Tomasselli, A.G.,Heinrikson, R.L.,Curry, K.A.,Tomich, C.S.,Thaisrivongs, S.,Sawyer, T.K.,Watenpaugh, K.D.; The crystallographic structure of the protease from human immunodeficiency virus type 2 with two synthetic peptidic transition state analog inhibitors.; J.Biol.Chem., 268:13103-13109, 1993; PubMed: 8514751

実験手法

X-RAY DIFFRACTION (2.5 Å)