1IV5

New Crystal Form of Human CD81 Large Extracellular Loop.

1IV5 の概要

• エントリーDOI: 10.2210/pdb1iv5/pdb
• 関連するPDBエントリー: 1G8Q
• 分子名称: CD81 antigen (2 entities in total)
• 機能のキーワード: alpha domain, five helix, immune system
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Multi-pass membrane protein: P60033
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 19834.15

構造登録者

Kitadokoro, K.,Bolognesi, M.,Grandi, G.,Marco, P.,Galli, G.,Petracca, R.,Fabiana, F. (登録日: 2002-03-14, 公開日: 2003-01-28, 最終更新日: 2024-10-16)

主引用文献

Kitadokoro, K.,Ponassi, M.,Galli, G.,Petracca, R.,Falugi, F.,Grandi, G.,Bolognesi, M.
Subunit Association and Conformational Flexibility in the Head-subdomain of Human CD81 Large Extracellular Loop.
Biol.Chem., 383:1447-1452, 2002

PubMed Abstract: The large extracellular loop of human CD81, a tetraspanin mediating hepatitis C virus envelope protein E2 binding to human cells, has been crystallized in a hexagonal form. The three-dimensional structure, solved and refined at 2.6 A resolution (R-factor = 22.8%), shows that the protein adopts a dimeric assembly, based on an association interface built up by tetraspanin-conserved residues. Structural comparisons with the tertiary structure of human CD81 large extracellular loop, previously determined in a different crystal form, show marked conformational fluctuations in the molecular regions thought to be involved in binding to the viral protein, suggesting rules for recognition and assembly within the tetraspan web.

PubMed: 12437138
DOI: 10.1515/BC.2002.164

実験手法

X-RAY DIFFRACTION (2.6 Å)