1ITG

CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HIV-1 INTEGRASE: SIMILARITY TO OTHER POLYNUCLEOTIDYL TRANSFERASES

Summary for 1ITG

Entry DOI	10.2210/pdb1itg/pdb
Descriptor	HIV-1 INTEGRASE, CACODYLATE ION (3 entities in total)
Functional Keywords	dna integration, dna binding (viral)
Biological source	Human immunodeficiency virus 1
Cellular location	Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P12497
Total number of polymer chains	1
Total formula weight	18468.74
Authors	Dyda, F.,Hickman, A.B.,Jenkins, T.M.,Engelman, A.,Craigie, R.,Davies, D.R. (deposition date: 1994-11-21, release date: 1995-05-08, Last modification date: 2024-02-07)
Primary citation	Dyda, F.,Hickman, A.B.,Jenkins, T.M.,Engelman, A.,Craigie, R.,Davies, D.R. Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases. Science, 266:1981-1986, 1994 Cited by PubMed: 7801124 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation