1ISQ

Pyrococcus furiosus PCNA complexed with RFCL PIP-box peptide

Summary for 1ISQ

Entry DOI	10.2210/pdb1isq/pdb
Related	1GE8
Descriptor	Proliferating Cell Nuclear Antigen, replication factor C large subunit (3 entities in total)
Functional Keywords	toroidal trimer, dna binding protein
Biological source	Pyrococcus furiosus More
Total number of polymer chains	2
Total formula weight	29385.87
Authors	Matsumiya, S.,Ishino, S.,Ishino, Y.,Morikawa, K. (deposition date: 2001-12-19, release date: 2002-10-23, Last modification date: 2024-10-30)
Primary citation	Matsumiya, S.,Ishino, S.,Ishino, Y.,Morikawa, K. Physical interaction between proliferating cell nuclear antigen and replication factor C from Pyrococcus furiosus Genes Cells, 7:911-922, 2002 Cited by PubMed Abstract: Proliferating cell nuclear antigen (PCNA), which is recognized as a DNA polymerase processivity factor, has direct interactions with various proteins involved in the important genetic information processes in Eukarya. We determined the crystal structure of PCNA from the hyperthermophilic archaeon, Pyrococcus furiosus (PfuPCNA) at 2.1 A resolution, and found that the toroidal ring-shaped structure, which consists of homotrimeric molecules, is highly conserved between the Eukarya and Archaea. This allowed us to examine its interaction with the loading factor at the atomic level. PubMed: 12296822 DOI: 10.1046/j.1365-2443.2002.00572.x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation