1ISQ

Pyrococcus furiosus PCNA complexed with RFCL PIP-box peptide

1ISQ の概要

• エントリーDOI: 10.2210/pdb1isq/pdb
• 関連するPDBエントリー: 1GE8
• 分子名称: Proliferating Cell Nuclear Antigen, replication factor C large subunit (3 entities in total)
• 機能のキーワード: toroidal trimer, dna binding protein
• 由来する生物種: Pyrococcus furiosus; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 29385.87

構造登録者

Matsumiya, S.,Ishino, S.,Ishino, Y.,Morikawa, K. (登録日: 2001-12-19, 公開日: 2002-10-23, 最終更新日: 2024-10-30)

主引用文献

Matsumiya, S.,Ishino, S.,Ishino, Y.,Morikawa, K.
Physical interaction between proliferating cell nuclear antigen and replication factor C from Pyrococcus furiosus
Genes Cells, 7:911-922, 2002

PubMed Abstract: Proliferating cell nuclear antigen (PCNA), which is recognized as a DNA polymerase processivity factor, has direct interactions with various proteins involved in the important genetic information processes in Eukarya. We determined the crystal structure of PCNA from the hyperthermophilic archaeon, Pyrococcus furiosus (PfuPCNA) at 2.1 A resolution, and found that the toroidal ring-shaped structure, which consists of homotrimeric molecules, is highly conserved between the Eukarya and Archaea. This allowed us to examine its interaction with the loading factor at the atomic level.

PubMed: 12296822
DOI: 10.1046/j.1365-2443.2002.00572.x

実験手法

X-RAY DIFFRACTION (2.3 Å)