1IRK

CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HUMAN INSULIN RECEPTOR

1IRK の概要

• エントリーDOI: 10.2210/pdb1irk/pdb
• 分子名称: INSULIN RECEPTOR TYROSINE KINASE DOMAIN, ETHYL MERCURY ION (3 entities in total)
• 機能のキーワード: transferase (phosphotransferase)
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P06213
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35252.11

構造登録者

Hubbard, S.R.,Wei, L.,Ellis, L.,Hendrickson, W.A. (登録日: 1995-01-02, 公開日: 1995-02-27, 最終更新日: 2024-02-07)

主引用文献

Hubbard, S.R.,Wei, L.,Ellis, L.,Hendrickson, W.A.
Crystal structure of the tyrosine kinase domain of the human insulin receptor.
Nature, 372:746-754, 1994

PubMed Abstract: The X-ray crystal structure of the tyrosine kinase domain of the human insulin receptor has been determined by multiwavelength anomalous diffraction phasing and refined to 2.1 A resolution. The structure reveals the determinants of substrate preference for tyrosine rather than serine or threonine and a novel autoinhibition mechanism whereby one of the tyrosines that is autophosphorylated in response to insulin, Tyr 1,162, is bound in the active site.

PubMed: 7997262
DOI: 10.1038/372746a0

実験手法

X-RAY DIFFRACTION (2.1 Å)