1IRG

INTERFERON REGULATORY FACTOR-2 DNA BINDING DOMAIN, NMR, 20 STRUCTURES

Summary for 1IRG

• Entry DOI: 10.2210/pdb1irg/pdb
• Descriptor: INTERFERON REGULATORY FACTOR-2 (1 entity in total)
• Functional Keywords: transcription regulation, winged helix-turn-helix
• Biological source: Mus musculus (house mouse)
• Cellular location: Nucleus: P23906
• Total number of polymer chains: 1
• Total formula weight: 13354.51

Authors

Furui, J.,Uegaki, K.,Yamazaki, T.,Shirakawa, M.,Swindells, M.B.,Harada, H.,Taniguchi, T.,Kyogoku, Y. (deposition date: 1997-11-25, release date: 1998-03-18, Last modification date: 2024-05-01)

Primary citation

Furui, J.,Uegaki, K.,Yamazaki, T.,Shirakawa, M.,Swindells, M.B.,Harada, H.,Taniguchi, T.,Kyogoku, Y.
Solution structure of the IRF-2 DNA-binding domain: a novel subgroup of the winged helix-turn-helix family.
Structure, 6:491-500, 1998

PubMed Abstract: The transcription of interferon (IFN) and IFN-inducible genes is mainly regulated by the interferon regulatory factor (IRF) family of proteins, which recognize a unique AAGTGA hexamer repeat motif in the regulatory region of IFN genes. A DNA-binding domain of approximately 100 amino acids has been commonly found in the IRF family of proteins, but it has no sequence homology to known DNA-binding motifs. Elucidation of the structures of members of the IRF family is therefore useful to the understanding of the regulation and evolution of the immune system at the structural level.

PubMed: 9562558
DOI: 10.1016/S0969-2126(98)00050-1

Experimental method

SOLUTION NMR