1IRF

INTERFERON REGULATORY FACTOR-2 DNA BINDING DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE

1IRF の概要

• エントリーDOI: 10.2210/pdb1irf/pdb
• 分子名称: INTERFERON REGULATORY FACTOR-2 (1 entity in total)
• 機能のキーワード: transcription regulation, winged helix-turn-helix
• 由来する生物種: Mus musculus (house mouse)
• 細胞内の位置: Nucleus: P23906
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 13354.51

構造登録者

Furui, J.,Uegaki, K.,Yamazaki, T.,Shirakawa, M.,Swindells, M.B.,Harada, H.,Taniguchi, T.,Kyogoku, Y. (登録日: 1997-11-24, 公開日: 1998-01-28, 最終更新日: 2024-05-01)

主引用文献

Furui, J.,Uegaki, K.,Yamazaki, T.,Shirakawa, M.,Swindells, M.B.,Harada, H.,Taniguchi, T.,Kyogoku, Y.
Solution structure of the IRF-2 DNA-binding domain: a novel subgroup of the winged helix-turn-helix family.
Structure, 6:491-500, 1998

PubMed Abstract: The transcription of interferon (IFN) and IFN-inducible genes is mainly regulated by the interferon regulatory factor (IRF) family of proteins, which recognize a unique AAGTGA hexamer repeat motif in the regulatory region of IFN genes. A DNA-binding domain of approximately 100 amino acids has been commonly found in the IRF family of proteins, but it has no sequence homology to known DNA-binding motifs. Elucidation of the structures of members of the IRF family is therefore useful to the understanding of the regulation and evolution of the immune system at the structural level.

PubMed: 9562558
DOI: 10.1016/S0969-2126(98)00050-1

実験手法

SOLUTION NMR