1IRA

COMPLEX OF THE INTERLEUKIN-1 RECEPTOR WITH THE INTERLEUKIN-1 RECEPTOR ANTAGONIST (IL1RA)

1IRA の概要

• エントリーDOI: 10.2210/pdb1ira/pdb
• 分子名称: INTERLEUKIN-1 RECEPTOR ANTAGONIST, INTERLEUKIN-1 RECEPTOR, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: cytokine receptor, receptor antagonist, immunoglobulin fold, complex (cytokine receptor-antagonist), complex (cytokine receptor-antagonist) complex, complex (cytokine receptor/antagonist)
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Isoform 1: Secreted. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm. Isoform 4: Cytoplasm: P18510; Membrane ; Single-pass type I membrane protein : P14778
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 54771.97

構造登録者

Schreuder, H.A.,Tardif, C.,Tramp-Kalmeyer, S.,Soffientini, A.,Sarubbi, E.,Akeson, A.,Bowlin, T.,Yanofsky, S.,Barrett, R.W. (登録日: 1998-04-09, 公開日: 1998-06-17, 最終更新日: 2023-08-09)

• 主引用文献: Schreuder, H.,Tardif, C.,Trump-Kallmeyer, S.,Soffientini, A.,Sarubbi, E.,Akeson, A.,Bowlin, T.,Yanofsky, S.,Barrett, R.W.; A new cytokine-receptor binding mode revealed by the crystal structure of the IL-1 receptor with an antagonist.; Nature, 386:194-200, 1997; PubMed: 9062194; DOI: 10.1038/386194a0

実験手法

X-RAY DIFFRACTION (2.7 Å)